Změnit instituci
Pokročilé nano a mikrotechnologie Pokročilé materiály Strukturní biologie Gen. a prot. rostlin. systémů Molekulární medicína Výzkum mozku a lidské mysli Molekulární vet. medicína

Life Sciences Seminar Series

Life Sciences Seminar Series

SPEAKER: Jeremy Green
King's College, London, UK
TOPIC: Between genotype and phenotype: signalling and physical morphogenesis at the cellular-to-supracellular level
WHEN: May 11, 2017, from 16:00
WHERE: Seminar room 132, pavilion A11, University Campus Bohunice, Brno

Abstract

Genes do not make tissues and organs: cells do. While great progress has been made in recent years in describing and understanding gene regulatory networks, these represent an essentially intracellular view of biology. Organismal phenotypes, particularly those affecting physical form and structure, are rarely analysed at the cellular-to-supracellular level. How ensembles of cells create form thus remains a significant frontier in research. General principles of tissue morphogenesis will be introduced with a particular focus on active cell rearrangement in epithelia as an organogenesis-driving process. Well known and novel morphogenetic motifs important in the formation of teeth, hair follicles and diverse glands in the body will be described. New discoveries relating physical phenotypes to the genes that control organ formation will be presented.

 

 

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