prof. RNDr. Šárka Pospíšilová, Ph.D.

2017

• KOTASKOVA, J; PAVLOVA, S; PLEVOVA, K; MALCIKOVA, J; STEHLIKOVA, O; POPPOVA, L; KOCKOVA, H; DOUBEK, M; BRYJA, V; POSPISILOVA, S, 2017:TREATMENT WITH BCR INHIBITORS INCREASES ROR1 EXPRESSION IN CLL CELLS. HAEMATOLOGICA 102 , p. 414 - 414.
• LEDEREROVA, A; KOZLOVA, V; VAKULOVA, V; DOUBEK, M; MAYER, J; POSPISILOVA, S; SMIDA, M, 2017:B CELLS RESISTANT TO CD20 MONOCLONAL ANTIBODIES DISPLAY SPECIFIC ALTERATIONS IN GENE EXPRESSION PROFILE. HAEMATOLOGICA 102 , p. 709 - 709.
• PAVLASOVA, G; BORSKY, M; SVOBODOVA, V; MUSILOVA, K; CERNA, K; SEDA, V; OSICKOVA, J; BRYCHTOVA, Y; DOUBEK, M; POSPISILOVA, S; MAYER, J; MRAZ, M, 2017:BCR SIGNALLING PROFICIENT CHRONIC LYMPHOCYTIC LEUKAEMIA B CELLS ARE PRONE TO RITUXIMAB MEDIATED ELIMINATION IN VIVO. HAEMATOLOGICA 102 , p. 412 - 412.
• PLEVOVA, K; MALCIKOVA, J; PAVLOVA, S; KOTASKOVA, J; POPPOVA, L; SMARDOVA, J; DIVISKOVA, E; DURECHOVA, K; OLTOVA, A; BRYCHTOVA, Y; PANOVSKA, A; DOUBEK, M; POSPISILOVA, S, 2017:BIALLELIC TP53 GENE MUTATIONS DUE TO COPY-NEUTRAL LOSS OF HETEROZYGOSITY AND MONOALLELIC MUTATIONS IN ABSENCE OF 17P DELETION OCCUR IN CLL WITH COMPARABLE FREQUENCY. HAEMATOLOGICA 102 , p. 65 - 66.
• VARDI, A; VLACHONIKOLA, E; KARYPIDOU, M; STALIKA, E; BIKOS, V; GEMENETZI, K; MARAMIS, C; SIORENTA, A; ANAGNOSTOPOULOS, A; POSPISILOVA, S; MAGLAVERAS, N; CHOUVARDA, I; STAMATOPOULOS, K; HADZIDIMITRIOU, A, 2017:Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements. LEUKEMIA 31 (7), p. 1555 - 1561.

2016

• BALIAKAS, P; MATTSSON, M; HADZIDIMITRIOU, A; MINGA, E; AGATHANGELIDIS, A; SUTTON, LA; SCARFO, L; DAVIS, Z; YAN, XJ; PLEVOVA, K; SANDBERG, Y; VOJDEMAN, FJ; TZENOU, T; CHU, CC; VERONEZE, S; MANSOURI, L; SMEDBY, KE; GIUDICELLI, V; NGUYEN-KHAC, F; PANAGIOTIDIS, P; JULIUSSON, G; ANAGNOSTOPOULOS, A; LEFRANC, MP; TRENTIN, L; CATHERWOOD, M; MONTILLO, M; NIEMANN, CU; LANGERAK, AW; POSPISILOVA, S; STAVROYIANNI, N; CHIORAZZI, N; OSCIER, D; JELINEK, DF; SHANAFELT, T; DARZENTAS, N; BELESSI, C; DAVI, F; GHIA, P; ROSENQUIST, R; STAMATOPOULOS, K, 2016:NO IMPROVEMENT IN LONG-TERM OVERALL SURVIVAL AFTER THE INTRODUCTION OF CHEMO(IMMUNO)THERAPY FOR CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS BELONGING TO STEREOTYPED SUBSET #2. HAEMATOLOGICA 101 , p. 231 - 231.
• BALIAKAS, P; PUIGGROS, A; XOCHELLI, A; SUTTON, LA; NGUYEN-KHAC, F; GARDINER, A; PLEVOVA, K; MINGA, E; HADZIDIMITRIOU, A; WALEWSKA, R; MCCARTHY, H; ORTEGA, M; COLLADO, R; GONZALEZ, T; GRANADA, I; LUNO, E; KOTASKOVA, J; MOYSIADIS, T; DAVIS, Z; STAVROYIANNI, N; ANAGNOSTOPOULOS, A; STREFFORD, JC; POSPISILOVA, S; DAVI, F; ATHANASIADOU, A; ROSENQUIST, R; OSCIER, D; ESPINET, B; STAMATOPOULOS, K, 2016:Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. HAEMATOLOGICA 101 (7), p. 299 - 302.
• BIKOS, V; KARYPIDOU, M; STALIKA, E; BALIAKAS, P; XOCHELLI, A; SUTTON, LA; PAPADOPOULOS, G; AGATHANGELIDIS, A; PAPADOPOULOU, E; DAVIS, Z; ALGARA, P; KANELLIS, G; TRAVERSE-GLEHEN, A; MOLLEJO, M; ANAGNOSTOPOULOS, A; PONZONI, M; GONZALEZ, D; POSPISILOVA, S; MATUTES, E; PIRIS, MA; PAPADAKI, T; GHIA, P; ROSENQUIST, R; OSCIER, D; DARZENTAS, N; TZOVARAS, D; BELESSI, C; HADZIDIMITRIOU, A; STAMATOPOULOS, K, 2016:An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. CLINICAL CANCER RESEARCH 22 (8), p. 2032 - 2040.
• JANOVSKA, P; POPPOVA, L; PLEVOVA, K; PLESINGEROVA, H; BEHAL, M; KAUCKA, M; OVESNA, P; HLOZKOVA, M; BORSKY, M; STEHLIKOVA, O; BRYCHTOVA, Y; DOUBEK, M; MACHALOVA, M; BASKAR, S; KOZUBIK, A; POSPISILOVA, S; PAVLOVA, S; BRYJA, V, 2016:Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia. CLINICAL CANCER RESEARCH 22 (2), p. 459 - 469.
• KOPPARAPU, PK; BHOI, S; MANSOURI, L; ARABANIAN, LS; PLEVOVA, K; POSPISILOVA, S; WASIK, AM; CROCI, GA; SANDER, B; PAULLI, M; ROSENQUIST, R; KANDURI, M, 2016:Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression. EPIGENETICS 11 (5), p. 335 - 343.
• KUBESOVA, B; PAVLOVA, S; MALCIKOVA, J; KABATHOVA, J; RADOVA, L; TOM, N; TICHY, B; PLEVOVA, K; KANTOROVA, B; FIEDOROVA, K; KISSOVA, J; GISSLINGER, B; GISSLINGER, H; MAYER, J; KRALOVICS, R; POSPISILOVA, S; DOUBEK, M, 2016:Low-Burden TP53 Mutations Occur in Chronic Phase of Myeloproliferative Neoplasms Regardless of Hydroxyurea Administration, Disease Type, and JAK2 Status. BLOOD 128 (22)
• PAVLASOVA, G; BORSKY, M; SEDA, V; CERNA, K; OSICKOVA, J; DOUBEK, M; MAYER, J; CALOGERO, R; POSPISILOVA, S; DAVIDS, M; BROWN, J; MRAZ, M, 2016:IBRUTINIB INHIBITS CD20 UP-REGULATION ON CLL B CELLS MEDIATED BY THE CXCR4/SDF-1 AXIS. HAEMATOLOGICA 101 , p. 47 - 47.
• POPPOVA, L; JANOVSKA, P; PLEVOVA, K; RADOVA, L; PLESINGEROVA, H; BORSKY, M; KOTASKOVA, J; KANTOROVA, B; HLOZKOVA, M; FIGULOVA, J; BRYCHTOVA, Y; DOUBEK, M; KOZUBIK, A; POSPISILOVA, S; PAVLOVA, S; BRYJA, V, 2016:DECREASED EXPRESSION OF WNT3, A CANONICAL WNT PATHWAY LIGAND, IS FREQUENT IN CHRONIC LYMPHOCYTIC LEUKEMIA PROGRESSION AND IDENTIFIES PATIENTS WITH SHORT TREATMENT-FREE SURVIVAL IN MUTATED IGHV SUBSET. HAEMATOLOGICA 101 , p. 423 - 424.
• POPPOVA, L; JANOVSKA, P; PLEVOVA, K; RADOVA, L; PLESINGEROVA, H; BORSKY, M; KOTASKOVA, J; KANTOROVA, B; HLOZKOVA, M; FIGULOVA, J; BRYCHTOVA, Y; MACHALOVA, M; URIK, M; DOUBEK, M; KOZUBIK, A; POSPISILOVA, S; PAVLOVA, S; BRYJA, V, 2016:Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV. BRITISH JOURNAL OF HAEMATOLOGY 175 (5), p. 851 - 859.
• POSPISILOVA, S; SUTTON, LA; MALCIKOVA, J; TAUSCH, E; ROSSI, D; MONTSERRAT, E; MORENO, C; STAMATOPOULOS, K; GAIDANO, G; ROSENQUIST, R; GHIA, P, 2016:Innovation In the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?. HAEMATOLOGICA 101 (3), p. 263 - 265.
• RAWSTRON, AC; FAZI, C; AGATHANGELIDIS, A; VILLAMOR, N; LETESTU, R; NOMDEDEU, J; PALACIO, C; STEHLIKOVA, O; KREUZER, KA; LIPTROT, S; O'BRIEN, D; DE TUTE, RM; MARINOV, I; HAUWEL, M; SPACEK, M; DOBBER, J; KATER, AP; GAMBELL, P; SOOSAPILLA, A; LOZANSKI, G; BRACHTL, G; LIN, K; BOYSEN, J; HANSON, C; JORGENSEN, JL; STETLER-STEVENSON, M; YUAN, C; BROOME, HE; RASSENTI, L; CRAIG, F; DELGADO, J; MORENO, C; BOSCH, F; EGLE, A; DOUBEK, M; POSPISILOVA, S; MULLIGAN, S; WESTERMAN, D; SANDERS, CM; EMERSON, R; ROBINS, HS; KIRSCH, I; SHANAFELT, T; PETTITT, A; KIPPS, TJ; WIERDA, WG; CYMBALISTA, F; HALLEK, M; HILLMEN, P; MONTSERRAT, E; GHIA, P, 2016:A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study. LEUKEMIA 30 (4), p. 929 - 936.
• SUTTON, LA; YOUNG, E; BALIAKAS, P; HADZIDIMITRIOU, A; MOYSIADIS, T; PLEVOVA, K; ROSSI, D; KMINKOVA, J; STALIKA, E; PEDERSEN, LB; MALCIKOVA, J; AGATHANGELIDIS, A; DAVIS, Z; MANSOURI, L; SCARFO, L; BOUDJOGHRA, M; NAVARRO, A; MUGGEN, AF; YAN, XJ; NGUYEN-KHAC, F; LARRAYOZ, M; PANAGIOTIDIS, P; CHIORAZZI, N; NIEMANN, CU; BELESSI, C; CAMPO, E; STREFFORD, JC; LANGERAK, AW; OSCIER, D; GAIDANO, G; POSPISILOVA, S; DAVI, F; GHIA, P; STAMATOPOULOS, K; ROSENQUIST, R, 2016:Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors. HAEMATOLOGICA 101 (8), p. 959 - 967.
• TURCHANINOVA, MA; DAVYDOV, A; BRITANOVA, OV; SHUGAY, M; BIKOS, V; EGOROV, ES; KIRGIZOVA, VI; MERZLYAK, EM; STAROVEROV, DB; BOLOTIN, DA; MAMEDOV, IZ; IZRAELSON, M; LOGACHEVA, MD; KLADOVA, O; PLEVOVA, K; POSPISILOVA, S; CHUDAKOV, DM, 2016:High-quality full-length immunoglobulin profiling with unique molecular barcoding. NATURE PROTOCOLS 11 (9), p. 1599 - 1616.
• ZAPRAZNA, K; MALCIKOVA, J; TOM, N; RADOVA, L; TRBUSEK, M; ATCHISON, M; POSPISILOVA, S, 2016:ACTIVATION INDUCED DEAMINASE SPLICE VARIANTS EXPRESSED IN B CELL LEUKEMIA AND LYMPHOMA DO NOT RETAIN THEIR CATALYTIC ACTIVITY. HAEMATOLOGICA 101 , p. 429 - 430.

2015

• AGATHANGELIDIS, A; BYSTRY, V; HADZIDIMITRIOU, A; SUTTON, LA; MINGA, E; KIENLE, D; DAVIS, Z; YAN, XJ; SHANAFELT, T; BOUDJOGRA, M; PLEVOVA, K; GOUNARI, M; XOCHELLI, A; NAVARRO, A; CHATZOULI, M; PEDERSEN, LB; BALIAKAS, P; SCARFO, L; ROSSI, D; VERONESE, S; FACCO, M; BIKOS, V; KARAN-DJURASEVIC, T; PAVLOVIC, S; MANSOURI, L; POIRON, C; CHU, CC; STALIKA, E; GIUDICELLI, V; PANAGIOTIDIS, P; SUDARIKOV, A; ANAGNOSTOPOULOS, A; TRENTIN, L; CATHERWOOD, M; MONTILLO, M; GAIDANO, G; CAMPO, E; GEISLER, CH; LANGERAK, AW; POSPISILOVA, S; LEFRANC, MP; CHIORAZZI, N; OSCIER, D; JELINEK, DF; STILGENBAUER, S; BELESSI, C; DAVI, F; ROSENQUIST, R; GHIA, P; DARZENTAS, N; STAMATOPOULOS, K, 2015:HIGHER-ORDER IMMUNOGLOBULIN SEQUENCE RELATIONS FOR MAJOR SUBSETS OF CHRONIC LYMPHOCYTIC LEUKEMIA: UNIQUENESS VERSUS EQUIVALENCE. HAEMATOLOGICA 100 , p. 47 - 48.
• BALIAKAS, P; HADZIDIMITRIOU, A; AGATHANGELIDIS, A; ROSSI, D; SUTTON, LA; KMINKOVA, J; SCARFO, L; POSPISILOVA, S; GAIDANO, G; STAMATOPOULOS, K; GHIA, P; ROSENQUIST, R, 2015:Prognostic relevance of MYD88 mutations in CLL: the jury is still out. BLOOD 126 (8), p. 1043 - 1044.
• BALIAKAS, P; HADZIDIMITRIOU, A; MATTSSON, M; XOCHELLI, A; SUTTON, LA; MINGA, E; SCARFO, L; ROSSI, D; DAVIS, Z; AGATHANGELIDIS, A; VILLAMOR, N; PARKER, H; KOTASKOVA, J; STALIKA, E; PLEVOVA, K; MANSOURI, L; CORTESE, D; LOPEZ, AN; DELGADO, J; LARRAYOZ, M; ANAGNOSTOPOULOS, A; BELESSI, C; SMEDBY, KE; JULIUSSON, G; STREFFORD, JC; POSPISILOVA, S; OSCIER, D; GAIDANO, G; CAMPO, E; GHIA, P; ROSENQUIST, R; STAMATOPOULOS, K, 2015:REFINING PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH SOMATICALLY HYPERMUTATED B-CELL RECEPTORS: A NOVEL PROGNOSTIC INDEX ON BEHALF OF THE EUROPEAN RESEARCH INITIATIVE ON CLL (ERIC). HAEMATOLOGICA 100 , p. 52 - 52.
• BALIAKAS, P; PUIGGROS, A; XOCHELLI, A; SUTTON, LA; NGUYEN-KHAC, F; GARDINER, A; PLEVOVA, K; ORTEGA, M; COLLADO, R; GONZALEZ, T; GRANADA, I; LUNO, E; KOTASKOVA, J; DAVIS, Z; ANAGNOSTOPOULOS, A; STREFFORD, J; POSPISILOVA, S; DAVI, F; ATHANASIADOU, A; ROSENQUIST, R; OSCIER, D; SOLA, BE; STAMATOPOULOS, K, 2015:ADDITIONAL TRISOMIES AMONGST PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA CARRYING TRISOMY 12: THE PARTNER CHROMOSOME MAKES A DIFFERENCE. HAEMATOLOGICA 100 , p. 224 - 224.
• BRAZDILOVA, K; PLEVOVA, K; FRANCOVA, HS; KOCKOVA, H; CHMELIKOVA, M; BORSKY, M; BURCKOVA, K; KANTOROVA, B; TICHY, B; SKABRAHOVA, H; BRYCHTOVA, Y; MAYER, J; DOUBEK, M; POSPISILOVA, S, 2015:Single Cell Analysis of IG Genes in CLL: Cases with Multiple IGH Rearrangements Are Constituted of Several Independent Clones Even When Indistinguishable By Flow Cytometry. BLOOD 126 (23)
• CHATZILARI, E; BALIAKAS, P; XOCHELLI, A; MARONIDIS, A; VARDI, A; MATTSSON, M; LARSSON, K; DOUKA, V; ISKAS, M; KARAVALAKIS, G; PAPALEXANDRI, A; NIEMANN, C; MONTILLO, M; ANAGNOSTOPOULOS, A; OSCIER, D; POSPISILOVA, S; DAVI, F; STAVROYIANNI, N; GHIA, P; HADZIDIMITRIOU, A; ROSENQUIST, R; NIKOLOPOULOS, S; STAMATOPOULOS, K; KOMPATSIARIS, Y, 2015:Personalized Modeling of Disease Evolution in CLL: Does Statistical Significance Translate into Predictive Accuracy?. BLOOD 126 (23)
• KANTOROVA, B; MALCIKOVA, J; BRAZDILOVA, K; BORSKY, M; PLEVOVA, K; SMARDOVA, J; TRBUSEK, M; BRYCHTOVA, Y; DOUBEK, M; MAYER, J; POSPISILOVA, S, 2015:Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia. BLOOD 126 (23)
• KOTASKOVA, J; MALCIKOVA, J; DIVISKOVA, E; PAVLOVA, S; MEJSTRIKOVA, S; VRANOVA, V; PLEVOVA, K; PLESINGEROVA, H; DOUBEK, M; MAYER, J; POSPISILOVA, S, 2015:13Q DELETION IS PREDOMINANT CYTOGENETIC ABERRATION NEWLY AQUIRED DURING CHRONIC LYMPHOCYTIC LEUKEMIA COURSE IRRESPECTIVE OF DISEASE ACTIVITY AND TREATMENT STATUS. HAEMATOLOGICA 100 , p. 417 - 418.
• LJUNGSTROM, V; CORTESE, D; YOUNG, E; PANDZIC, T; MANSOURI, L; PLEVOVA, K; SUTTON, LA; STAVROYIANNI, N; AGATHANGELIDIS, A; ROSSI, D; HOGLUND, M; OSCIER, D; GAIDANO, G; DAVI, F; POTT, C; TRENTIN, L; POSPISILOVA, S; GHIA, P; STAMATOPOULOS, K; SJOBLOM, T; ROSENQUIST, R, 2015:DISSECTING RESISTANCE MECHANISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING WHOLE-EXOME SEQUENCING: IMPACT OF RECURRENT RPS15 MUTATIONS ON P53 DYSREGULATION. HAEMATOLOGICA 100 , p. 10 - 11.
• NAVRKALOVA, V; KAFKOVA, LR; DIVOKY, V; POSPISILOVA, S, 2015:Oxidative stress as a therapeutic perspective for ATM-deficient chronic lymphocytic leukemia patients. HAEMATOLOGICA 100 (8), p. 994 - 996.
• NAVRKALOVA, V; YOUNG, E; BALIAKAS, P; RADOVA, L; PLEVOVA, K; SUTTON, LA; MANSOURI, L; LJUNGSTROM, V; NTOUFA, S; DAVIS, Z; JULIUSSON, G; SMEDBY, KE; BELESSI, C; PANAGIOTIDIS, P; DAVI, F; LANGERAK, AW; GHIA, P; STREFFORD, JC; OSCIER, DG; STAMATOPOULOS, K; POSPISILOVA, S; ROSENQUIST, R; TRBUSEK, M, 2015:ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome. BLOOD 126 (23)
• NOERENBERG, D; YOUNG, E; LJUNGSTROM, V; MANSOURI, L; PLEVOVA, K; BALIAKAS, P; BLAKEMORE, S; ROSSI, D; CLIFFORD, R; NAVRKALOVA, V; SUTTON, LA; SMEDBY, KE; JULIUSSON, G; BELESSI, C; PANAGIOTIDIS, P; CHIORAZZI, N; DAVI, F; LANGERAK, AW; SCHUH, A; GAIDANO, G; STREFFORD, JC; GHIA, P; STAMATOPOULOS, K; POSPISILOVA, S; ZENZ, T; ROSENQUIST, R; DAMM, F, 2015:EGR2 Mutations in Chronic Lymphocytic Leukemia: A New Bad Player. BLOOD 126 (23)
• PAVLASOVA, G; SEDA, V; BORSKY, M; CERNA, K; OSICKOVA, J; MAYER, J; POSPISILOVA, S; DAVIDS, MS; BROWN, JR; MRAZ, M, 2015:Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination. BLOOD 126 (23)
• PLESINGEROVA, H; JANOVSKA, P; POPPOVA, L; SHAIK, A; JURCICKOVA, Z; LIBRA, A; PLEVOVA, K; MACHAC, J; SLAPAK, I; PAVLOVA, S; OVESNA, P; KOTASKOVA, J; DOUBEK, M; POSPISILOVA, S; BRYJA, V, 2015:UPREGULATED COBLL1 IN CHRONIC LYMPHOCYTIC LEUKAEMIA (CLL) PATIENTS WITH UNMUTATED IGHV IDENTIFIES A COHORT WITH INFERIOR PROGNOSIS. HAEMATOLOGICA 100 , p. 50 - 50.
• TOM, N; MALCIKOVA, J; RADOVA, L; KANTOROVA, B; PARDY, F; PAVLOVA, S; PAL, K; MRAZ, M; TICHY, B; DOUBEK, M; BRYCHTOVA, Y; PLEVOVA, K; MAYER, J; TRBUSEK, M; POSPISILOVA, S, 2015:MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 100 , p. 224 - 225.
• VARDI, A; KARIPIDOU, M; GEMENETZI, A; VLACHONIKOLA, E; BIKOS, V; STALIKA, E; KORAVOU, E; MARAMIS, C; SIORENTA, A; ANAGNOSTOPOULOS, A; POSPISILOVA, S; MAGLAVERAS, N; CHOUVARDA, I; STAMATOPOULOS, K; HADZIDIMITRIOU, A, 2015:Next Generation Sequence Immunoprofiling of the T-Cell Repertoire in Chronic Lymphocytic Leukemia Supports Selection By Shared Antigenic Elements. BLOOD 126 (23)
• VARDI, A; STALIKA, E; GKOUFAS, A; KARIPIDOU, M; MARAMIS, C; BIKOS, V; POSPISILOVA, S; ANAGNOSTOPOULOS, A; MAGLAVERAS, N; CHOUVARDA, I; STAMATOPOULOS, K; HADZIDIMITRIOU, A, 2015:HIGH-THROUGHPUT T-CELL RECEPTOR GENE REPERTOIRE PROFILING IN CHRONIC LYMPHOCYTIC LEUKEMIA SUBSET #4: FURTHER EVIDENCE OF ANTIGENIC STIMULATION. HAEMATOLOGICA 100 , p. 11 - 12.
• XOCHELLI, A; BIKOS, V; POLYCHRONIDOU, E; AGATHANGELIDIS, A; CHARLOTTE, F; MOSCHONAS, P; DAVIS, Z; COLOMBO, M; ROUMELIOTI, M; SUTTON, LA; GROENEN, P; BOUDJOGHRA, M; ALGARA, P; TRAVERSE-GLEHEN, A; FERRER, A; STALIKA, E; KARYPIDOU, M; KANELLIS, G; KALPADAKIS, C; MOLLEJO, M; PANGALIS, G; VLAMOS, P; AMINI, RM; POSPISILOVA, S; GONZALEZ, D; PONZONI, M; ANAGNOSTOPOULOS, A; GIUDICELLI, V; LEFRANC, MP; ESPINET, B; PANAGIOTIDIS, P; PIRIS, MA; DU, M; ROSENQUIST, R; PAPADAKI, T; BELESSI, C; FERRARINI, M; OSCIER, D; TZOVARAS, D; GHIA, P; DAVI, F; HADZIDIMITRIOU, A; STAMATOPOULOS, K, 2015:Unique Versus Common: Disease-Biased Immunoglobulin Gene Repertoires Along with Public Antigen Receptor Stereotypes in Marginal Zone B-Cell Lymphoproliferations. BLOOD 126 (23)

2014

• BALIAKAS, P; HADZIDIMITRIOU, A; SUTTON, LA; MINGA, E; AGATHANGELIDIS, A; TSANOUSA, A; SCARFO, L; DAVIS, Z; YAN, XJ; SHANAFELT, T; PLEVOVA, K; SANDBERG, Y; VOJDEMAN, FJ; BOUDJOGRA, M; TZENOU, T; CHATZOULI, M; CHU, CC; VERONESE, S; GARDINER, A; MANSOURI, L;, 2014:NOT ALL IGHV3-21 CLL ARE EQUAL: SUBSET #2 DISPLAYS A DISTINCTIVE CLINICOBIOLOGICAL PROFILE WITH REMARKABLE SIMILARITIES TO SUBSET #169, ITS CLOSE IMMUNOGENETIC RELATIVE. HAEMATOLOGICA 99 , p. 48 - 49.
• DOUBEK, M; SROVNAL, J; PLEVOVA, K; TRIZULJAK, J; BRYCHTOVA, Y; SEMERAD, L; LETALOVA, E; BENEDIKOVA, A; MAYER, J; HAJDUCH, M; POSPISILOVA, S, 2014:ANALYSIS OF MERKEL CELL POLYOMAVIRUS PROGNOSTIC SIGNIFICANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 99 , p. 325 - 325.
• NAVRKALOVA, V; MARECKOVA, A; JANIKOVA, A; DOUBEK, M; MAYER, J; POSPISILOVA, S; TRBUSEK, M, 2014:INCORPORATION OF NEXT-GENERATION SEQUENCING INTO ATM GENE ANALYSIS IN PATIENTS WITH CLL AND MCL. HAEMATOLOGICA 99 , p. 312 - 312.
• POLANSKA, E; POSPISILOVA, S; STROS, M, 2014:Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1. PLOS ONE 9 (2)
• ROBESOVA, B; BAJEROVA, M; LISKOVA, K; SKRICKOVA, J; TOMISKOVA, M; POSPISILOVA, S; MAYER, J; DVORAKOVA, D, 2014:TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC. LUNG CANCER 85 (1), p. 25 - 30.
• SHUGAY, M; BRITANOVA, OV; MERZLYAK, EM; TURCHANINOVA, MA; MAMEDOV, IZ; TUGANBAEV, TR; BOLOTIN, DA; STAROVEROV, DB; PUTINTSEVA, EV; PLEVOVA, K; LINNEMANN, C; SHAGIN, D; POSPISILOVA, S; LUKYANOV, S; SCHUMACHER, TN; CHUDAKOV, DM, 2014:Towards error-free profiling of immune repertoires. NATURE METHODS 11 (6), p. 653 - +.
• SUTTON, LA; LJUNGSTROM, V; MANSOURI, L; YOUNG, E; CORTESE, D; NAVRKALOVA, V; MALCIKOVA, J; MUGGEN, AF; TRBUSEK, M; DAVI, F; BELESSI, C; LANGERAK, AW; GHIA, P; POSPISILOVA, S; STAMATOPOULOS, K; ROSENQUIST, R, 2014:TARGETED NEXT-GENERATION SEQUENCING FOR MUTATIONAL SCREENING IN CHRONIC LYMPHOCYTIC LEUKEMIA: A HIGH-THROUGHPUT YET TAILORED APPROACH WILL FACILITATE IMPLEMENTATION WITHIN A CLINICAL SETTING. HAEMATOLOGICA 99 , p. 313 - 314.
• VERNER, J; TRBUSEK, M; CHOVANCOVA, J; SKABRAHOVA, H; JASKOVA, Z; MOULIS, M; FOLBER, F; HALOUZKA, R; MAYER, J; POSPISILOVA, S; DOUBEK, M, 2014:NOD/SCID GAMMA XENOGRAFT MODEL OF B-CELL MALIGNANCIES USING TP53-AND/OR ATM-DEFICIENT CELL LINES. HAEMATOLOGICA 99 , p. 312 - 313.
• XOCHELLI, A; AGATHANGELIDIS, A; KAVAKIOTIS, I; MINGA, E; SUTTON, LA; BALIAKAS, P; CHOUVARDA, I; GIUDICELLI, V; VLAHAVAS, I; MAGLAVERAS, N; BONELLO, L; TRENTIN, L; MONTILLO, M; PANAGIOTIDIS, P; GEISLER, C; LANGERAK, AW; POSPISILOVA, S; JELINEK, DF; OSCIER,, 2014:IMMUNOGLOBULIN HEAVY VARIABLE GENES AND ALLELES: NEW ENTITIES, NEW NAMES AND IMPLICATIONS FOR RESEARCH AND PROGNOSTICATION IN CLL. HAEMATOLOGICA 99 , p. 49 - 49.

2013

• KAUCKA, M; PLEVOVA, K; PAVLOVA, S; JANOVSKA, P; MISHRA, A; VERNER, J; PROCHAZKOVA, J; KREJCI, P; KOTASKOVA, J; OVESNA, P; TICHY, B; BRYCHTOVA, Y; DOUBEK, M; KOZUBIK, A; MAYER, J; POSPISILOVA, S; BRYJA, V, 2013:The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration. CANCER RESEARCH 73 (5), p. 1491 - 1501.
• KHARE, V; LYAKHOVICH, A; DAMMANN, K; LANG, M; BORGMANN, M; TICHY, B; POSPISILOVA, S; LUCIANI, G; CAMPREGHER, C; EVSTATIEV, R; PFLUEGER, M; HUNDSBERGER, H; GASCHE, C, 2013:Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. BIOCHEMICAL PHARMACOLOGY 85 (2), p. 234 - 244.
• KREJCI, M; DOUBEK, M; BRYCHTOVA, Y; STEHLIKOVA, O; CHOVANCOVA, J; TICHY, B; FRANCOVA, HS; NAVRATIL, M; TOMISKA, M; HORKY, O; POSPISILOVA, S; MAYER, J, 2013:Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia. ANNALS OF HEMATOLOGY 92 (2), p. 249 - 254.

2012

• AGATHANGELIDIS, A; DARZENTAS, N; HADZIDIMITRIOU, A; BROCHET, X; MURRAY, F; YAN, XJ; DAVIS, Z; VAN GASTEL-MOL, EJ; TRESOLDI, C; CHU, CC; CAHILL, N; GIUDICELLI, V; TICHY, B; PEDERSEN, LB; FORONI, L; BONELLO, L; JANUS, A; SMEDBY, K; ANAGNOSTOPOULOS, A; MERLE, 2012:Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. BLOOD 119 (19), p. 4467 - 4475.
• DOLEZALOVA, D; MRAZ, M; BARTA, T; PLEVOVA, K; VINARSKY, V; HOLUBCOVA, Z; JAROS, J; DVORAK, P; POSPISILOVA, S; HAMPL, A, 2012:MicroRNAs Regulate p21(Waf1/Cip1) Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells. STEM CELLS 30 (7), p. 1362 - 1372.
• JANIKOVA, A; MARECKOVA, A; DVORAKOVA, D; BORTLICEK, Z; TICHY, B; NAVRATIL, M; KRAL, Z; POSPISILOVA, S; MAYER, J, 2012:A real-time (PCR) for a real life ...? Quantitative evaluation of BCL2/IGH in follicular lymphoma and its implications for clinical practice. EXPERIMENTAL HEMATOLOGY 40 (7), p. 528 - 539.
• KOSTARELI, E; GOUNARI, M; JANUS, A; MURRAY, F; BROCHET, X; GIUDICELLI, V; POSPISILOVA, S; OSCIER, D; FORONI, L; DI CELLE, PF; TICHY, B; PEDERSEN, LB; JURLANDER, J; PONZONI, M; KOUVATSI, A; ANAGNOSTOPOULOS, A; THOMPSON, K; DARZENTAS, N; LEFRANC, MP; BELESS, 2012:Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. LEUKEMIA 26 (5), p. 1127 - 1131.
• KOZUBIK, KS; MALCIKOVA, J; TRBUSEK, M; TOM, N; DOUBEK, M; BRYCHTOVA, Y; SMARDOVA, J; MAYER, J; POSPISILOVA, S; TICHY, B, 2012:Clonal Selection of TP53 Mutations in Chronic Lymphocytic Leukaemia Detected by Ultra-deep Pyrosequencing. EUROPEAN JOURNAL OF CANCER 48 , p. S146 - S146.
• LENGEROVA, M; KOCMANOVA, I; RACIL, Z; HRNCIROVA, K; POSPISILOVA, S; MAYER, J; NAJVAR, LK; WIEDERHOLD, NP; KIRKPATRICK, WR; PATTERSON, TF, 2012:Detection and Measurement of Fungal Burden in a Guinea Pig Model of Invasive Pulmonary Aspergillosis by Novel Quantitative Nested Real-Time PCR Compared with Galactomannan and (1,3)-beta-D-Glucan Detection. JOURNAL OF CLINICAL MICROBIOLOGY 50 (3), p. 602 - 608.
• MRAZ, M; DOLEZALOVA, D; PLEVOVA, K; KOZUBIK, KS; MAYEROVA, V; CERNA, K; MUSILOVA, K; TICHY, B; PAVLOVA, S; BORSKY, M; VERNER, J; DOUBEK, M; BRYCHTOVA, Y; TRBUSEK, M; HAMPL, A; MAYER, J; POSPISILOVA, S, 2012:MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. BLOOD 119 (9), p. 2110 - 2113.
• MRAZ, M; POSPISILOVA, S, 2012:MicroRNAs in chronic lymphocytic leukemia: from causality to associations and back. EXPERT REVIEW OF HEMATOLOGY 5 (6), p. 579 - 581.

2011

• JANIKOVA, A; TICHY, B; SUPIKOVA, J; STANO-KOZUBIK, K; POSPISILOVA, S; KREN, L; VASOVA, I; SALEK, D; MAYER, J, 2011:Gene expression profiling in follicular lymphoma and its implication for clinical practice. LEUKEMIA & LYMPHOMA 52 (1), p. 59 - 68.
• MRAZ, M; ZENT, CS; CHURCH, AK; JELINEK, DF; WU, XS; POSPISILOVA, S; ANSELL, SM; NOVAK, AJ; KAY, NE; WITZIG, TE; NOWAKOWSKI, GS, 2011:Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance. BRITISH JOURNAL OF HAEMATOLOGY 155 (1), p. 53 - 64.
• TRBUSEK, M; SMARDOVA, J; MALCIKOVA, J; SEBEJOVA, L; DOBES, P; SVITAKOVA, M; VRANOVA, V; MRAZ, M; FRANCOVA, HS; DOUBEK, M; BRYCHTOVA, Y; KUGLIK, P; POSPISILOVA, S; MAYER, J, 2011:Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia. JOURNAL OF CLINICAL ONCOLOGY 29 (19), p. 2703 - 2708.
• VARGOVA, K; CURIK, N; BURDA, P; BASOVA, P; KULVAIT, V; POSPISIL, V; SAVVULIDI, F; KOKAVEC, J; NECAS, E; BERKOVA, A; OBRTLIKOVA, P; KARBAN, J; MRAZ, M; POSPISILOVA, S; MAYER, J; TRNENY, M; ZAVADIL, J; STOPKA, T, 2011:MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. BLOOD 117 (14), p. 3816 - 3825.

2010

• KOTASKOVA, JANA; TICHY, BORIS; TRBUSEK, MARTIN; FRANCOVA, HANA SKUHROVA; KABATHOVA, JITKA; MALCIKOVA, JITKA; DOUBEK, MICHAEL; BRYCHTOVA, YVONA; MAYER, JIRI; POSPISILOVA, SARKA, 2010:High Expression of Lymphocyte-Activation Gene 3 (LAG3) in Chronic Lymphocytic Leukemia Cells Is Associated with Unmutated lmmunoglobulin Variable Heavy Chain Region (IGHV) Gene and Reduced Treatment-Free Survival. JOURNAL OF MOLECULAR DIAGNOSTICS 12 (3), p. 328 - 334.
• MALCIKOVA, J; TICHY, B; DAMBORSKY, J; KABATHOVA, J; TRBUSEK, M; MAYER, J; POSPISILOVA, S, 2010:Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation. BIOLOGICAL CHEMISTRY 391 (2 III), p. 197 - 205.

2009

• MRAZ, M., MALINOVA, K., KOTASKOVA, J., PAVLOVA, S., TICHY, B., MALCIKOVA, J., STANO-KOZUBIK, K., SMARDOVA, J., BRYCHTOVA, Y., DOUBEK, M., TRBUSEK, M., MAYER, J., POSPISILOVA, S., 2009:miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia 23 (6), p. 1159 - 1163.

Pracoviště 1:	Masarykova univerzita - CEITEC MU Kamenice 753/5, Brno, 625 00, kancelář bud. A35/257
Pracoviště 2:	Masarykova univerzita Jihlavská 20, Brno, 625 00